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But many users, like Diaz, are experiencing an alarming boomerang effect once they go off the drug, gaining all their weight back and often, much more

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The SURMOUNT-1 trial (Jastreboff et al., NEJM , 2022) showed tirzepatide at its highest dose produced average weight loss of over 22% of body weight, compared to roughly 15% for semaglutide at maximum dose in the STEP 1 trial