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Pregnant or Breastfeeding Women: The increased nutritional needs during pregnancy and breastfeeding may require B12 supplementation to support both mother and child

Furthermore, dihydrobiopterin plays a role in maintaining the reduced state of tetrahydrofolate, so the clinical phenotype of dihydrobiopterin deficiency is similar to that of dihydrofolate reductase deficiency

Gallagher RC, Van Hove JLK, Scharer G, Hyland K, Plecko B, Waters PJ, et al

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Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum