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Dose increase: at Day 16 inside the on phase, the dose steps from the low end to the high end of the range

Rebates are a contributing factor to rising list prices, because a manufacturer is incentivized to start negotiations with a high list price and then negotiate down to the net price so it can offer PBMs a higher rebate (but with a more profitable net price) and receive favorable formulary treatment

Pindborg JJ

Dihexa activates the c-Met receptor pathway, which is also involved in certain cancers creating a theoretical oncogenic concern

Platanosides, a potential botanical drug combination, decrease liver injury caused by acetaminophen overdose in mice

Wu G, Fang Y-Z, Yang S, Lupton JR, Turner ND