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Schommers et al., 2017) and modified the expression of genes related to mitochondria (Yang et al., 2021), potentially leading to a rise in anaerobic glucose metabolism

Appetite Suppression and Satiety Enhancement Dual GIP/GLP-1 activation powerfully reduces food intake through central and peripheral signaling, increases satiety, and delays gastric emptying

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Nevertheless, the dual mechanism of action of tirzepatidecombining GLP-1mediated appetite suppression with GIP-driven improvements in insulin sensitivity and lipid metabolismrepresents a promising therapeutic strategy that warrants further investigation in adolescent-specific clinical trials