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Oral sermorelin is destroyed before it gets anywhere near the pituitary
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DOI: 10.1016/s0272-6386(03)00110-0 Malaguarnera M, Cammalleri L, Gargante MP, Vacante M, Colonna V, Motta M
Tesamorelin signals through the GHRH receptor (GHRH-R), a class B G-protein-coupled receptor expressed on anterior pituitary somatotrophs, via Gs/cAMP/PKA signaling that drives growth hormone gene transcription and exocytosis of pre-formed growth hormone from secretory granules [2]
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FEBS J ;286(5):826854
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