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The adaptor protein DDB1 (DNA damaging-binding protein 1) binds CULLIN4A/B-RBX1 complex and interacts with multiple WD40-repeat proteins (WDRs) to regulate cell cycle progression and DNA damage response 8

NPJ Parkinsons Dis 8:82

Sex distribution and mean age are also listed for each brain region based on diagnosis group (as the number of participants collected varied for each brain region

Abstract Restricting amino acids from tumours is an emerging therapeutic strategy with substantial promise 1

The cysteine modification is expected to trigger a conformational change of the Keap1 homodimer, which could dissociate the weak binding site, the DLG motif (latch), from the Keap1 DC domain, while the strong binding site, the ETGE motif (hinge), remains attached to the other Keap1 DC domain

& Evangelou, E