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applied a molecular hybridization technique in 2023 to introduce a new family of ascidian-celecoxib COX inhibitors using a hydrazone linker (103)

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Kuras R, Reszka E, Wieczorek E, et al

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Results Electrochemical detection of glutathione in different tissues and fluids of control and angiotensin-II treated rats using HPLC/ECD A significant decrease in GSH was detected in cardiac tissue, kidney, liver and plasma of hypertensive, AT-II-treated rats ( Optical detection of GSH and protein-bound thiols by derivatization of plasma samples by Ellmans reagent in different tissues and fluids of normotensive and hypertensive rats using HPLC Levels of free NTB from the reaction of reduced thiols (including low-molecular-weight thiols such as GSH and free cysteine as well as protein-bound thiols) with DTNB were significantly decreased in almost all of the analyzed tissues and fluids except in the liver of AT-II-treated rats ( Photometric detection of glutathione and glutathione disulfide in different tissues and fluids of angiotensin-II-treated rats Using a commercial photometric assay kit, the GSH/GSSG ratio was determined and revealed a significant decrease only for heart tissue of hypertensive animals when compared to controls