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Although 25 selenoproteins are tissue-specific finetuned in Se deficiency (85) and deiodinase is a highly conserved selenoprotein, the content activity of deiodinase also decreases in severe Se deficiency, when the body synthesizes significantly less T3 and the inhibitory effect on TSH is diminished
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These effects appear to include both: upregulation of genes involved in repair suppression of genes associated with inflammation and tissue degradation In some experimental models, GHK has been shown to restore gene expression patterns associated with youthful tissue physiology
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