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While semaglutide itself does not directly impact menstrual cycles, significant weight loss or changes in metabolism, which are common with semaglutide use, can influence hormonal balance and potentially affect menstrual patterns

doi:10.1016/bs.vh.2022.09.002 3 Losada-Barreiro, Sonia et al

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Today, however, some users may cycle on and off the drugs every few months, or microdose, to get the benefits of the medication without the side effectsor to better manage the high cost of the drugs

Safety Like any of the companies providing compounded medications, the safety of those treatments will align with the quality of the compounding pharmacy the company uses