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Br J Radiol

(Encinitas) 13 , 812 (2014)

Lactate elicits vascular endothelial growth factor from macrophages: a possible alternative to hypoxia

It works by increasing levels of dopamine and serotonin , two neurotransmitters associated with the brains reward system

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In REDEFINE 1 (overweight/obesity without T2D), CagriSema achieved mean weight reductions of 20.4-22.7% (vs 2.3-3.0% placebo) at 68 weeks, with 53.6% and 34.7% of patients achieving 20% and 25% weight loss, respectively