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Experimental procedure included 20L as injection volume with a flow rate of 0.7 mL/min, ESI negative ionization, a dwell time of 50 ms, and MRM transitions
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doi: 10.1111/jhn.12385 16
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Meanwhile, aldehyde groups form Schiff bases with tissue amines, enhancing adhesion and retention to support sustained delivery to subchondral bone and inhibit osteoclast differentiation and bone resorption
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