The Johns Hopkins University
Others feel fatigued because appetite suppression leads to chronic under-eating, low protein intake, dehydration, low electrolytes, poor sleep, constipation, rapid weight loss, or reduced muscle mass
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The heart compensates for this loss of power by enlarging, developing more muscle, pumping faster, narrowing blood vessels, and diverting blood to vital organs
A meta-analysis of seven SURPASS clinical trials in participants with T2DM showed the hazard ratios comparing tirzepatide versus controls of 0.80 (95% CI, 0.57 1.11) for 4-MACE, 0.90 (95% CI, 0.50 1.61) for cardiovascular death, and 0.80 (95% CI, 0.51 1.25) for all-cause mortality (264)
But people like Loren report the drugs, which manage blood sugar and treat obesity, have muted or altered tastes