Intravenous delivery of glutathione circumvents the body's slow and frequently ineffective digestion process
52 An implication of this model is that ferroptotic contagion may, under certain conditions, behave analogously to other excitable biological wave systems, such as calcium waves or spreading depolarization, in which local activation is continuously regenerated rather than physically transmitted over long distances
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After blocking, the membrane was incubated overnight at 4 C with the specified primary antibodies, including TRPM2 antibody at a dilution of 1:1000 and GAPDH antibody at a dilution of 1:3000
institutional requirements
This post-translational modification is now recognised as a major mechanism of redox-regulated cell signalling, controlling the activity of transcription factors, kinases, phosphatases, and metabolic enzymes in response to the intracellular redox environment