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A massive 2024/2025 observational study published in PNAS (MedRxiv preprint) analyzed data from over 3,925 patients suffering from Long COVID and ME/CFS
doi: 10.21608/ejrs.2017.41826 169
Higher levels are linked to better insulin sensitivity, lower inflammation, and a stronger gut barrier
The functions of SCFAs are involved in modulating energy metabolism, regulating immune and inflammatory responses, and inhibiting oxidative stress and mitochondrial damage, which are mainly through the activation of transmembrane G protein-coupled receptors (GPRs) and the inhibition of Histone deacetylase activity (HDAC)
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