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J Clin Invest 127:2432

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Forced expression of these miRNAs in prostate cancer cells, PC3 and LNCaP, results in reduced expression of CPT1A, CAC, and CAT, and hence, negatively affects FAO

(3) Inhibiting Adipose Tissue Inflammation and Improving the Adipose Microenvironment In obesity, adipose tissue develops chronic lowgrade inflammation with abundant release of proinflammatory factors (such as TNF and IL6), disrupting the adipose microenvironment, further worsening fat metabolic abnormalities and insulin resistance, and forming a vicious cycle