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The released ROS activate the ion channel TRPM2 in macrophages, promoting calcium influx, thereby eliciting an immune response

10.1002/mnfr.201200332 52 Prez-TavarezR.CarreraM.PedrosaM.QuirceS.Rodrguez-PrezR.GassetM

Poor Diet A diet high in processed foods, sugars, and unhealthy fat s can reduce the body's ability to synthesize glutathione, leading to increased oxidative stress

Not catastrophic, but worth knowing, especially if your last dose from a vial seems to come up short

While its helpful to understand the mechanics of a B12 injection, putting that knowledge into practice is another story

If you are self-supplementing with high doses, discuss this with your GP to ensure it is appropriate and safe for your individual circumstances