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Moreover, this mutant had upregulated expression of GSTU19 and GSTU13 highly correlated with virus limitation in the resistance-like reaction ( Atgstu24 mutants also characterized the upregulated activity of GR

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However, their incremental cost-effectiveness ratios were USD 197,023/QALY and USD 467,676/QALY, respectively, indicating that price reductions of ~30% (tirzepatide) and ~82% (semaglutide) would be required to meet the conventional threshold of USD 100,000/QALY

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