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Maintenance can be as little as a few months to forever

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YH25724, a novel long-acting GLP-1/FGF21 dual agonist provides potent and sustained glycaemic control, body weight loss and lipid profile improvement in animal models [abstract 111]

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Research from Nature Metabolism shows that beta-arrestin1, a protein that normally limits the insulin response to GLP-1, does not limit the insulin response to GIP or tirzepatide