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Published pharmacokinetic work describes a plasma half-life of only a few minutes after intravenous administration

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The compounds require injection, and access can be limited due to cost and shortages

For pediatric patients, we recommend focusing on foundational health strategies such as proper nutrition, gut support, and lifestyle modifications to promote overall well-being

Ann Rheum Dis (2015) 74(1):1926

However, we will be looking forward to novel local and systemic mechanisms, molecules and agents that would be able to improve this concept by pharmacological therapy