The gap that remains is a large-scale, placebo-controlled, double-blind randomized clinical trial of topical GHK-Cu specifically for androgenetic alopecia
The vast majority of patients feel fine and benefit from the injection without any problems
Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau
PGC-1alpha and mitochondrial-biogenesis markers
Always talk to your doctor about the risks and benefits of any treatment
avoid timing doses around large meals, since food blunts the GH response