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Byrne MM, et al

They are often sold as research chemicals or for topical cosmetic use, and pre-mixed pens intended for injection are not approved by the MHRA (Medicines and Healthcare products Regulatory Agency)

Wilsons Disease or other copper metabolism disorders are absolute contraindications because the additional copper delivery could cause dangerous accumulation

Although some of the natural ingredients used in these patches, such as berberine, have shown in some studies to slightly increase GLP-1 levels, regulate blood sugar levels and promote weight loss 8 , their efficiency through transdermal methods is not yet proven and needs to be studied further 3