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10.1081/CLT-100102388
A study of 30 patients with type 2 diabetes treated for 8 weeks showed measurable reductions in CD62p (a marker of platelet activation) and PAC-1 (a marker of glycoprotein IIb/IIIa complex activation, the final common pathway of platelet aggregation)
If you plateau at a sub-maximal dose, escalation is the logical next step
If side effects are intolerable despite dietary modifications, dose reduction or temporary treatment interruption may be necessary, with subsequent slower re-titration once symptoms resolve
Major distributors now carry the medication, and most pharmacies can order it within a few days if not immediately stocked
Spontaneous reports through systems like the MHRA Yellow Card scheme cannot establish frequency or definitively confirm causality
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