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Use in individuals under 18 is not recommended without specific healthcare provider guidance

For instance, in two included trials, younger PD subjects in the placebo group exhibited greater and more rapid motor deterioration, as measured by the MDS-UPDRS Part III subscale, compared to their older counterparts [30, 38]

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Patients who use them have no clinical supervision, no baseline labs, no dosing protocol designed for their biology, and no provider to consult if something goes wrong

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