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Novel approaches such as organoids, vascularized tumor-on-chip models, and genetically engineered mouse models with inducible vascular and oncogenic mutations may better replicate the interplay between tumor biology and cardiovascular stress

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For 2025, the focus has moved even further toward individualized, outcomes-driven care, emphasizing early combination therapy, cardiovascular risk management, and digital health integration

Some trials report significantly reduced oxidative markers versus a control group, though results vary by dose, route, and baseline levels

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