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The most promising compounds, 39 and 40 (Figure 6), showed an IC 50 of 2.80 nM against DPP-4 catalytic activity, with 20 - 40-fold selectivity over the DPP-8 and DPP-9 isozymes

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This forms a bilayer: water-attracting heads on the outside, water-repelling tails on the inside, enshrining the cargo

Wharton S, Batterham RL, Bhatta M, et al

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Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists