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As dietary fiber is vital for maintaining the colonic mucus barrier, fiber deficiency favors the proliferation of distinct microbial populations that degrade the colonic mucus layer and enable enhanced colonization and infiltration of opportunistic pathogens (Desai et al., 2016)

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Contrast to peptides, small-molecule GLP-1 agonists like orforglipron are synthesized via conventional chemical routes in organic solvents, which can be scaled more like typical pharmaceuticals (crystallization, distillation, continuous reactors)

[56], found lower fasting and postprandial GLP-1 levels compared with healthy controls, suggesting a relative deficiency of meal-related GLP-1 signaling

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