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For most nonpregnant, non-breastfeeding people without specific allergies, adverse events are limited to mild and transient flu-like effects and (for injectables) injection site reactions

They must be reconstituted before they can be used for research or therapeutic applications

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They are most useful in the first few days of an acute injury or during an osteoarthritis or bursitis episode

Common reactions can include fatigue, nausea, headache, or lightheadedness during or after an injection