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Obesity For weight loss, healthcare professionals may prescribe GLP-1 agonists for people with an initial BMI of 30 or higher or people who have a BMI of 27 or higher and at least one weight-related health condition, such as: type 2 diabetes prediabetes high blood pressure high cholesterol heart disease nonalcoholic fatty liver disease obstructive sleep apnea polycystic ovary syndrome Typically, healthcare professionals only prescribe these medications after someone has tried other weight loss methods, such as diet and exercise, without success

Bottom line: If you experience gastrointestinal distress, try shifting your dose to 1-2 hours before sleep to see if your symptoms improve

While it is known that skin cells can produce estrogens locally, aromatase enzyme activity is dramatically reduced to approximately 30 times lower than in premenopausal ovarian follicular tissue [10]

PMID: 34789012 Chen, K., et al

This dual approach may help patients adhere to reduced-calorie eating patterns more comfortably

But damage is occurring