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In more extreme cases, you may be advised to follow the work of Andreas Moritz, whose book The Amazing Liver & Gallbladder Flush, details how you can partake in a more extensive flush at home

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A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction