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B., Malecka-Panas, E., Ardizzone, S., D'Arienzo, A., Valpiani, D., Koch, M., Denapiene, G., Vago, G., Fociani, P., Zerbi, P., Ceracchi, M., Camerini, R., and Gasbarrini, G

Ampomah PB, Cai B, Sukka SR, Gerlach BD, Yurdagul A, Wang X, et al

The intake of capsules containing 500 mg of curcumin powder (1500 mg per day) for 12 weeks significantly decreases glucose and DHEA levels in patients with PCOS11

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Any disruption along this pathway can lead to deficiency regardless of dietary intake, which is why some patients need supplementation even when they eat B12-rich foods