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What works for one person might cause significant side effects for another
In the SURMOUNT trials evaluating tirzepatide for chronic weight management (Zepbound), constipation occurred in 17-26% of patients depending on the dose, compared to 4% in the placebo group
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Spironolactone is also not safe in pregnancy because of its anti-androgen effects, so pregnancy avoidance is essential if there is any chance of conception
Without GSH depletion, exposure to both AQ-QI and DEAQ-QI increased caspase 3 activity by 60%
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