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Mast cell activation and histamine intolerance overlap with oxalate sensitivity in a couple of ways: A study involving cell samples from patients with kidney stones found that they had higher mast cell counts than a healthy control group.[ref] Ketotifen, a drug that stops mast cell degranulation, reduces the formation of calcium oxalate kidney stones.[ref] Interestingly, the reason that stinging nettles cause severe skin irritation is that they contain oxalic acid and tartaric acid, which have been shown to activate mast cells.[ref][ref] Related article : Mast cell activation syndrome and Histamine intolerance Inflammation: Macrophage activation by oxalate crystals Macrophages are a type of white blood cell that can exist in an anti-inflammatory state (M2) that promotes healing or in a pro-inflammatory state (M1) that increases ROS and inflammation

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doi: 10.1016/j.jmb.2020.11.005, 85 MeiM.ZhouY.LiuM.ZhaoF.WangC.DingJ.et al

ConsumerLab answer explains the best way to take vitamins and minerals

British journal of clinical pharmacology, 72 (1), 2738