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These cells secrete cytokines and growth factors, including IL1, IL-6, IL8, TNF, VEGF, CCL5, RANTES
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Sleep apnea The SURMOUNT-OSA trial demonstrated that tirzepatide reduced the severity of obstructive sleep apnea significantly, with some patients achieving complete resolution
However, when the mice were treated with Dihexa, levels of both IL-1-beta and TNF-alpha were found to significantly decrease
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How it works The best-documented mechanism runs through VEGFR2, a receptor that triggers new blood vessel formation, paired with the Akt-eNOS pathway, which generates nitric oxide to support vascular repair and restore blood flow to damaged tissue (Rodgers et al., 2025)
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