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Primary carnitine deficiency (PCD) is a rare autosomal recessive disorder of fatty acid oxidation caused by deficiency of plasma membrane carnitine transport resulting from impairment in the plasma membrane OCTN2 carnitine transporter

Although N-acetylcysteine (NAC) directly influences the pool of extracellular cystine and intracellular cysteine via a series of plasmatic redox reactions, in order to be effective, intracellular cysteine precursors must be designed to enter erythrocytes rapidly and use high activity enzymes within erythrocytes to liberate cysteine (Whillier et al., 2009

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Being a potent antioxidant, it lessens oxidative stress and neutralizes free radicals, two key causes of cellular damage

As an aside, piperlongumine has an effect on restraining FTC cell growth and cell cycle, inducing apoptosis and autophagy by PI3K/AKT pathway [292]

many also have carnitine deficiency