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Following the daily ICV injection of Lira and Exe-9 on both groups, the body weight, food intake, and FBG were monitored, where the results indicated that during the whole process, more or less, Lira strengthened the effects of DJB and ameliorated T2DM in the Sham group by reducing body weight, food intake, and normalizing the glycemic status, whereas the Exe-9 showed a reverse impact (Fig