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While moderate amounts can support gut and immune function, too much can thin this barrier, leading to increased intestinal permeability (leaky gut), inflammation and immune dysregulation An overgrowth of Akkermansia is linked to Multiple sclerosis, Parkinsons disease, Colorectal cancer, and Autoimmune flares So while the idea of taking a probiotic to boost GLP-1, and therefore reduce appetite or support blood sugar, sounds promising, forcing the gut ecosystem out of balance can backfire

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Study selection Firstly, studies were assessed by title verification between databases (duplicates were removed)

Semaglutide hits one target, the GLP-1 receptor

10.1172/JCI67227 42 SalemK

Due to their different intended uses, Wegovy and Ozempic are available in varying doses, reflecting the distinct needs of their target patients