Tate et al (31) reported that exendin-4 exerted an effect on paracrine communication between macrophages and cardiac fibroblasts, which may provide an explanation for the observation of the present study
The researchers conducted a meta-analysis of phase 3 clinical trials
Improvements in anxiety, depression, and a reductions in suicidal ideation and suicide attempts appear substantial
What to watch Phase 1 readouts on first-in-human pharmacokinetics typically come 6 to 12 months after dosing starts
Results: Meta-analysis showed a statistically significant effect of curcumin on depressive symptoms (SMD: 0.65, P = 0.01, 95% CI: 1.16 to 0.13, I 2 = 93%) and anxiety symptoms (SMD: 0.22, P = 0.01, 95% CI: 0.40 to 0.05, I 2 = 0%)
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