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Enhanced organizational permeability The increase in molecular weight does not significantly affect its ability to penetrate tissues and can still effectively act on deep cells

Glossary DR diabetic retinopathy NVU neurovascular unit BRB blood-retinal barrier IL-1 interleukin-1 TNF- tumor necrosis factor-alpha HC healthy controls T2DM type 2 diabetes mellitus STING stimulator of interferon genes IL-10 interleukin-10 IL-22 interleukin-22 Tregs regulatory T cells TGF- transforming growth factor-beta IL-1 interleukin-1 beta IL-6 interleukin-6 IL-8 interleukin-8 IL-17 interleukin-17 IFN- interferon-gamma MCP-1 monocyte chemoattractant protein-1 ICAM-1 intercellular adhesion molecule-1 CD36 cluster of differentiation 36 VCAM-1 vascular cell adhesion molecule-1 VEGF vascular endothelial growth factor LPS lipopolysaccharide NLRP3 nod-like receptor protein 3 IL-18 interleukin-18 TLR4 toll-like receptor 4 MyD88 myeloid differentiation primary response protein 88 iNOS inducible nitric oxide synthase JNK c-jun n-terminal kinase IKK ikB kinase IRS insulin receptor substrate SCFAs short-chain fatty acids CCL 2 chemokine (C-C motif) ligand 2 CCL 8 chemokine (C-C motif) ligand 8 CXCL 5 chemokine (C-X-C motif) ligand 5 CXCL 8 chemokine (C-X-C motif) ligand 8 CXCL 10 chemokine (C-X-C motif) ligand 10 H4 histone H4 GPCRs G protein-coupled receptors GPR41 G protein-coupled receptor 41 GPR43 G protein-coupled receptor 43 BSH bile salt hydrolases TLR2 toll - like receptor 2 Th17 th17 - polarizing cytokines IL - 17 interleukin - 17 IL - 23 interleukin - 23 IL - 17A interleukin - 17A IL - 17R interleukin - 17 receptor FADD fas - associated death domain JAK/STAT Janus Kinase/Signal Transducer and Activator of Transcription RPE retinal pigment epithelium IL-4 interleukin-4 mtDNA mitochondrial DNA RMECs retinal microvascular endothelial cells cGAS cyclic GMP-AMP synthase CXCL 12 C - X - C motif chemokine 12 CXCL1 C - X - C motif chemokine 1 RACs retinal astrocytes TUDCA tauroursodeoxycholic acid TGR5 G protein-coupled receptor 5 BAs bile acids TMAO trimethylamine N-oxide HRMECs human retinal microvascular endothelial cells ROS reactive oxygen species PBMCs peripheral blood mononuclear cells ASC caspase recruitment domain SGLT2 sodium-glucose cotransporter 2 - GI alpha - glucosidase TCM traditional Chinese medicine SZ - A sangzhi total alkaloids tablets LTF luo tong fang CQLT compound qilian tablets APS astragalus polysaccharide Iba - 1 ionized calcium - binding adaptor molecule 1 FMT fecal microbiota transplantation References 1 WangRWangQYBaiYBiYGCaiSJ

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