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Key point: Weight loss is a delayed effect

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ER-mitochondria associations are regulated by the VAPBPTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

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Others may require dose escalation or maximal doses to experience an effect, and studies show that 20% of individuals are complete non-responders, meaning they do not experience any weight reduction despite maximal doses of the drug. With this in mind, the average experience with GLP-1s includes a gradual onset of benefits, says Dr