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Titration is the process of gradually adjusting the dose of a medication to find the right amount that provides maximum benefits with minimal side effects

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Eligible patients were aged 45 years with a BMI of 27 kg m 2 and established ASCVD, defined as at least one of the following: prior MI, prior ischemic or hemorrhagic stroke, or symptomatic peripheral artery disease)

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This Review discusses the functional inter-relationships between erythropoietin, iron and inflammatory mediators under physiologic conditions and in relation to the pathogenesis of renal anaemia, as well as recent insights into the molecular and cellular basis of erythropoietin production in the kidney