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The good news is that even with some weight fluctuation, the improved proportions often remain
Tirzepatide activates both GIP and GLP-1 receptors (dual agonist), while semaglutide only targets GLP-1
GLP-1 is primarily synthesized and secreted by specialized enteroendocrine cells called L-cells, which are located throughout the intestinal tract but are most concentrated in the distal small intestine (ileum) and colon
GLP-1 receptors are widely distributed in the central nervous system, especially in regions related to appetite regulation, memory, and learning, including the hippocampus, hypothalamus, and brainstem
Seno, A