Tirzepatide, a dual GLP-1 / glucose-dependent insulinotropic polypeptide (GIP) agonist, was superior to semaglutide in reducing HbA 1c and body weight in the SURPASS-2 trial, a phase 3, randomised, open-label trial comparing the efficacy and safety of tirzepatide vs semaglutide once weekly as add-on therapy to metformin in individuals with type 2 diabetes [10]
Realistic expectations : Modest improvements
Ozempic (semaglutide) is a GLP-1 receptor agonist widely prescribed for type 2 diabetes management in the UK
Orforglipron is an oral non-peptide GLP-1 agonist that could solve the injection barrier entirely
The antinociceptive impact of DSIP was negated by the opioid antagonist naloxone and was not observed in morphine-tolerant mice, suggesting that DSIP acts at the supraspinal level, possibly influencing opioid receptors [11]
Alternatively, ibuprofen (200-400 mg every 6-8 hours with food, not exceeding 1200 mg daily for OTC use) can provide both pain relief and anti-inflammatory effects