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The weight-lowering effects of GLP-1 RAs are mediated through multiple, interrelated mechanisms
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Exenatide (EC 50 = 0.60 nM, E max = 125%) and liraglutide (EC 50 = 1.8 nM, E max = 117%) were 380- and 130-fold more potent, respectively, and caused somewhat greater receptor internalization relative to PF-06882961 (Table S5)
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