glp-1 long term safety As Use Expands, Long-Term Questions Remain Under Watch Kaplan-Meier curves showing the long-term

In the TRIUMPH-1 Phase 3 trial, participants on the maximum dose of retatrutide (12 mg) lost an average of 28.3% of their body weight after 80 weeks, and up to 30.3% after 104 weeks in the study extension

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Astrocyte dysfunction, beyond disrupting water and potassium homeostasis through altered AQP4 and Kir4.1 expression, amplifies neuroinflammation around degenerating motor neurons, exacerbating their deterioration

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Where the medications diverge: Semaglutide is typically started at 0.25 mg weekly for four weeks, then increased to 0.5 mg

Observations relating to the impact of tirzepatide on bone are still very much in their infancy, but there are suggestions that this drug could improve bone strength and reduce fracture risk