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It is a fair concern

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Clinical trials of tirzepatide show that GI side effects are among the most common adverse reactions, but most side effects reported in studies were mild to moderate, temporary, and occurred primarily after starting the medication or increasing the dosage

For instance, some individuals think they will stop taking them once theyve lost weight while others are only using them cosmetically and not for management of a chronic disease. Call for more research In a new JAMA Viewpoint opinion piece, Khan and others call for more research to understand the causes of this discontinuation and the development of clinical and policy interventions to support long-term use

As compounded GLP-1 RAs continue to fill gaps caused by shortages or cost barriers, clinicians must exercise heightened vigilance, ensure use of reputable compounding sources, and provide robust patient education

It may also increase low blood sugar risk when used with insulin or sulfonylureas