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Regarding the HDL levels, there was no between-study heterogeneity (I 2 = 0.0%)

Drug: Trevogrumab (REGN-1033), anti-myostatin monoclonal antibody Developer: Regeneron Pharmaceuticals Trial: COURAGE (Phase 2), 599 patients randomized Lead investigator: Julio Rosenstock, M.D., UT Southwestern / Velocity Clinical Research Best result: 92.6% of weight loss from fat (triplet combo) Timeline: Phase 3 expected 2027

Benefits become apparent after 8-12 weeks

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