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Week two through three usually brings more noticeable pain reduction

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Thom SR, Fisher D, Xu YA, Garner S, Ischiropoulos H

If taking higher doses, it is highly recommended to split the administration (e.g., one dose in the morning and one in the early afternoon) to maintain steady blood levels of the active compounds throughout the day

Low vitamin D levels are especially prevalent during the winter months, when daylight is shorter and people spend more time indoors

in Methods in Enzymology Vol