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Magnesium Threonate: The only form of magnesium that effectively crosses the Blood-Brain Barrier

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B 2 -containing cofactors are also needed by enzymes that activate vitamins B 12 and B 6

Nutrition and Hydration Collagen synthesis requires adequate protein intake, particularly amino acids like glycine, proline, and hydroxyproline

With aging, SN neurons in primates gradually transition from dopaminergic neurons, identified by the presence of the DA-synthesizing enzyme tyrosine hydroxylase (TH), to dopaminergic neurons expressing neuromelanin and eventually to cells that do not synthesize dopamine (TH-negative) but have neuromelanin [4]