In my clinical experience, most women with MCAS or histamine intolerance can safely use bioidentical hormone therapy if it is chosen and timed thoughtfully
Both male and female hormones are secreted by the adrenal cortex, but their quantity is small and their effects are usually masked by the hormones from the testes and ovaries.In Adrenal Exhaustion, the masculinization effect of androgen secretion may become evident after menopause or under stress when estrogen levels from the ovaries decrease in absolute terms but increase in relative terms in a state of estrogen dominance
These changes promote systemic inflammation and may directly contribute to HS development [87]
Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetes
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Always consult your provider about the best options for your unique goals.