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Originally developed as an anti-obesity therapeutic, it has a strong safety profile from Phase II clinical trials and was even granted GRAS (Generally Recognised as Safe) status by the FDA for use in food products making its Category 2 classification particularly puzzling

However, more pathways do not automatically mean a medication is right for every person

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Margins recommended in New Zealand (2013): Melanoma in situ: 510 mm Melanoma 2 mm: 20 mm Australian Clinical Practice Guidelines for the diagnosis and management of melanoma (updated 2018), recommend, where possible: Melanoma in situ: 5 mm, and wider margins if appropriate Melanoma 4 mm: 20 mm Systemic therapy If the melanoma is widespread, surgical treatment is not always successful in eradicating cancer

But when done correctly, a creatine regimen can be a valuable aid to athletic performance

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